Developing anti-TNF and biologic agents
نویسندگان
چکیده
منابع مشابه
Developing anti-TNF and biologic agents.
We have witnessed unprecedented advances in the past quarter of the century in our understanding of the pathophysiology of RA. Fortunately, for the majority of people presenting with this condition today, the outlook is much better than it would have been for those a generation ago. Many contemporary trainees in rheumatology might listen with incredulity when their senior colleagues describe th...
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OBJECTIVES To evaluate prevalence of dose escalation among RA patients in normal clinical practice treated with etanercept, adalimumab or infliximab and to estimate its economic impact. METHODS A retrospective observational study of 739 patients with RA receiving continuous treatment with etanercept (n=319), adalimumab (n=313) or infliximab (n=107) for 18 months. Dose escalation, intensificat...
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BACKGROUND Anti-TNF agents have proven efficacy in children with severe juvenile idiopathic arthritis (JIA) who are unresponsive to standard therapy. Therefore pain reduction or elimination could be expected. The aim of this study was to compare the pain experience in children with JIA treated with anti-TNF agents (n = 41) or non-biologic standard treatment (n = 50). METHODS All children comp...
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OBJECTIVE To obtain detailed real-world data on persistence and dosing patterns in the utilisation of the TNF inhibitors adalimumab, etanercept, and infliximab in rheumatoid arthritis (RA) patients treated in Germany. METHODS In this retrospective observational study claims data of a major German health insurance fund between 2005 and 2008 were analysed. Patients receiving at least one prescr...
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Transmembrane TNF-alpha, a precursor of the soluble form of TNF-alpha, is expressed on activated macrophages and lymphocytes as well as other cell types. After processing by TNF-alpha-converting enzyme (TACE), the soluble form of TNF-alpha is cleaved from transmembrane TNF-alpha and mediates its biological activities through binding to Types 1 and 2 TNF receptors (TNF-R1 and -R2) of remote tiss...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2011
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/ker235